diff --git a/gnu/packages/bioconductor.scm b/gnu/packages/bioconductor.scm
index c81b967a086..35495dd5776 100644
--- a/gnu/packages/bioconductor.scm
+++ b/gnu/packages/bioconductor.scm
@@ -2678,14 +2678,14 @@ includes channel names, protein marker names, and protein marker classes.")
 (define-public r-illumina450probevariants-db
   (package
     (name "r-illumina450probevariants-db")
-    (version "1.44.0")
+    (version "1.46.0")
     (source (origin
               (method url-fetch)
               (uri (bioconductor-uri "Illumina450ProbeVariants.db"
                                      version 'experiment))
               (sha256
                (base32
-                "0iwaf1psi44537d86q5w9yr5qh3yzqlpr0jhr2fjjplvmwc989zz"))))
+                "07q21x5hya6lrdj2f2ssm7s98768bh8099fzwc87s9k57kif074y"))))
     (properties `((upstream-name . "Illumina450ProbeVariants.db")))
     (build-system r-build-system)
     (home-page "https://bioconductor.org/packages/Illumina450ProbeVariants.db")